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Miles Scott
Miles Scott

Buy L Methylfolate



Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.




buy l methylfolate



WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Large quantities of methylfolate may mask the effects of pernicious anemia. If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use. Keep out of reach of children. Store in a cool, dry place.


Objective: The authors conducted two multicenter sequential parallel comparison design trials to investigate the effect of L-methylfolate augmentation in the treatment of major depressive disorder in patients who had a partial response or no response to selective serotonin reuptake inhibitors (SSRIs).


Method: In the first trial, 148 outpatients with SSRI-resistant major depressive disorder were enrolled in a 60-day study divided into two 30-day periods. Patients were randomly assigned, in a 2:3:3 ratio, to receive L-methylfolate for 60 days (7.5 mg/day for 30 days followed by 15 mg/day for 30 days), placebo for 30 days followed by L-methylfolate (7.5 mg/day) for 30 days, or placebo for 60 days. SSRI dosages were kept constant throughout the study. In the second trial, with 75 patients, the design was identical to the first, except that the l-methylfolate dosage was 15 mg/day during both 30-day periods.


Results: In the first trial, no significant difference was observed in outcomes between the treatment groups. In the second trial, adjunctive L-methylfolate at 15 mg/day showed significantly greater efficacy compared with continued SSRI therapy plus placebo on both primary outcome measures (response rate and degree of change in depression symptom score) and two secondary outcome measures of symptom severity. The number needed to treat for response was approximately six in favor of adjunctive L-methylfolate at 15 mg/day. L-Methylfolate was well tolerated, with rates of adverse events no different from those reported with placebo.


Conclusions: Adjunctive L-methylfolate at 15 mg/day may constitute an effective, safe, and relatively well tolerated treatment strategy for patients with major depressive disorder who have a partial response or no response to SSRIs.


The patient stated that she had quit her full-time job in 2014 and had since been working from home only part-time, though her stress remained high. She exercised 30 minutes each morning, and stretched each evening. She also danced and played soccer regularly. She received counseling every 3-4 weeks, and acupuncture regularly, which had only been somewhat effective for symptom relief. She had self-prescribed an extensive list of supplements in an effort to elevate mood and energy, but only small improvements resulted. Her daily supplements included, but were not limited to, vitamin D3 3000 IU, L-methylfolate 1 mg, vitamins B6 and B12, a multivitamin with iron, and many herbal formulations designed for support of adrenal gland function.


The patient stated that she had already been supplementing with L-methylfolate 1 mg for many weeks. She was instructed to increase her supplementation to 2 mg daily for 1 week, and increase by 1-2 mg per week until a total of 15 mg was achieved. A slow titration of the supplement was advised to avoid certain known side effects, including gastrointestinal distress, anxiety, and/or agitation. L-methylfolate has mostly been studied as an add-on therapy in higher doses (15 mg daily) with an SSRI or other antidepressant, but may also be an effective monotherapy for patients with MDD.10,11


L-methylfolate is a medical food for use in people who have conditions related to folate deficiency. L-methylfolate is also used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency.


L-methylfolate is only part of a complete program of treatment that may also include other medications, and psychological counseling when used in people with depression or schizophrenia. Follow your medication and counseling routines very closely.


This list is not complete. Other drugs may interact with l-methylfolate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.


MethylPro L-methylfolate is a highly effective and bioavailable form of folate that has been scientifically proven to be capable of crossing the blood-brain barrier. This unique substance can aid in the normal production of serotonin, norepinephrine, dopamine as well as help convert homocysteine into methionine. It's especially beneficial for those with genetic variations which limit their ability to use regular forms of folates effectively since it provides an alternate source supporting healthy moods, cardiovascular health and nerve function.


Any folic acid we ingest must be metabolised (converted) into Dihydrofolate (DHF), Tetrahydrofolate (THF), and then finally into L-methylfolate (5-MTHF) to be used in the body. Once in this form it can be transported into cells, tissues and even across the blood-brain barrier.


Summary: Any folic acid or folate we ingest must be converted into its active form (L-methylfolate) to be useful. However this becomes a problem if you cannot do this conversion effectively, such as those with an MTHFR mutation.


L-methylfolate is becoming widely recognised as an effective complementary medicine for patients with severe depression. That is, using it alongside pharmaceutical drugs (SSRI) to enhance the overall effectiveness of treatment (much like fish oil and depression).


Several randomised clinical trials have shown that 15 mg/day of L-methylfolate calcium is a safe, effective and well-tolerated treatment for patients with major depressive disorder who experience partial or no response to SSRIs (11, 12).


In a recent study, 544 patients with diabetic neuropathy were given Metanx (L-methylfolate-methylcobalamin-pyridoxal-5-phosphate) to trial for over a year. Based on self-reported surveys, overall pain rating decreased by 32% those previously treated with medications reported a 52% improvement in medication satisfaction (15).


Summary: There a very important factors to consider before taking L-methylfolate. Side-effects are also common and potentially dangerous if you do not address the problem immediately.


If this is you, I recommend this supplement (disclosure: this is an affiliate link). The reason is because it contains 800 mcg of L-methylfolate (start with half) plus 1 milligram of vitamin B12 per pill.


Denovo is a new, active form of folate priced significantly lower than similar brands and generic L methylfolate supplements. DENOVO PLUS B12 is a dietary supplement used for the metabolic management of low folate & B12 levels associated with symptoms of depression. Patients with symptoms of depression often exhibit low levels of folate & vitamin B12. The human body needs sufficient folate intake to produce the essential neurotransmitters serotonin, dopamine, & norepinephrine. These neurotransmitters alleviate feelings of sadness, anxiety, & gloom. Vitamin B12 helps the body use fats & carbohydrates to create energy, stimulate serotonin production, & reduce stress when taking a minimum of 500 mcg (1/2 mg) daily.


Uses: Denovo is indicated for the distinct metabolic requirements of individuals who have suboptimal L-methylfolate levels in the cerebrospinal fluid, plasma, and or red blood cells and have major depressive disorder (MDD) with particular emphasis as adjunctive support for individuals who are on an antidepressant medication.


L-methylfolate supplements are also used in people with major depressive disorder who have folate deficiency or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency. (Source UofMH) 041b061a72


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